Requirement of basolateral amygdala neuron activity for the induction of long-term potentiation in the dentate gyrus in vivo.
نویسندگان
چکیده
We investigated the effect of injection of a local anesthetic, tetracaine, into the ipsilateral basolateral amygdala (BLA) on long-term potentiation (LTP) in the medial perforant path-dentate gyrus granule cell synapses of anesthetized rats. The dentate gyrus synaptic potential evoked by low frequency test stimulation did not change following tetracaine injection into BLA. However, when tetanic stimulation (30 pulses at 60 Hz) was applied 10 min after tetracaine injection, the magnitude of LTP was significantly attenuated in a dose-dependent manner. Injection of tetracaine after tetanic stimulation did not affect the established LTP. The small LTP observed in the BLA-lesioned rats was regarded as the BLA-independent component of LTP, which was not affected by tetracaine injection. These results suggest that neuron activities in the ipsilateral BLA are partly required for the induction of LTP in the dentate gyrus in vivo.
منابع مشابه
Effect of Clenbuterol Administration into the Basolateral Amygdala on Synaptic Plasticity in Dentate Gyrus Granule Cells in Male Rats
Background and purpose: Neural circuits and neurotransmitter systems within the basolateral amygdala (BLA) play roles in forming emotional memory through communication with the hippocampus. Therefore, in this study, the role of these neural circuits on synaptic plasticity was investigated by agonist injection of beta-adrenergic receptors into the BLA. Materials and methods: In this experiment...
متن کاملLow-power density of 950 MHz radiation does not affect long-term potentiation in rat dentate gyrus
Introduction: Over the last decade, exposure to non-ionizing electromagnetic waves due to base station antenna has increased. This in vivo study was planned for evaluating the effects of whole-body exposure to 950 MHz field of GSM mobile phone system on rat dentate gyrus long-term potentiation. Materials and Methods: 24 naive male Wistar rats (3 month old, 225|¡|25 g) were randomly divided in t...
متن کاملAmygdala N-methyl-D-aspartate receptors participate in the induction of long-term potentiation in the dentate gyrus in vivo.
We investigated the effects of injection of N-methyl-D-aspartate (NMDA) receptor antagonists, 2-amino-5-phosphonovalerate (APV) and 7-chlorokynurenate (7-Cl-Kyn), into the basolateral amygdala (BLA) on long-term potentiation (LTP) in the medial perforant path-dentate gyrus granule cell synapses of anesthetized rats. Injection of APV or 7-Cl-Kyn into the ipsilateral BLA did not affect the baseli...
متن کاملHigh-frequency stimulation of the basolateral amygdala facilitates the induction of long-term potentiation in the dentate gyrus in vivo.
We investigated the effect of high-frequency stimulation of the basolateral amygdala (BLA) on the induction of long-term potentiation (LTP) in the medial perforant path (PP)-dentate gyrus (DG) synapses of anesthetized rats. A conditioning stimulation (100 pulses at 100 Hz) of the ipsilateral BLA did not change the DG synaptic potential. However, when the BLA conditioning stimulation was applied...
متن کاملEffect of forced treadmill exercise on long-term potentiation (LTP) in the dentate gyrus of hippocampus in male rats
Introduction: Previous studies indicate that exercise influences cognitive function. Nevertheless, considering that exercise in animal study can be voluntary, or forced, effects of exercise (specially forced exercise) on learning and memory abides as a matter of controversy. The present study aimed to investigate the effects of treadmill exercise on LTP in the dentate gyrus of rats. Methods: T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Brain research
دوره 671 2 شماره
صفحات -
تاریخ انتشار 1995